Removing SORLA protein from drug-resistant HER2-positive cancer cell lines

Novel therapy-resistance mechanism promoting the growth of breast cancer brain metastasis
SORLA removal sensitises metastatic breast cancer cells to HER2 targeting therapy. Aggressive metastatic breast cancer cells growing in the brains of fish embryos. The tumors are resistant to anti-HER2 therapy alone but sensitive when anti-HER2 therapy is combined with SORLA depletion. Credit: Dr Ilkka Paatero from Turku Bioscience Zebrafish Core Facility

SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells. Professor Johanna Ivaska’s research group at Turku Bioscience observed that SORLA functionally contributes to the most reported therapy-resistant mechanism by which the cell-surface receptor HER3 counteracts HER2

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